Endocrine Abstracts

Objective: To investigate if the event of late-onset circulatory collapse (LCC) implicated in dysfunction of adrenal steroidgenesis due to impairment of adrenal remodeling in preterm infants.Methods: Eleven in the patient group (case) with clinical signs compatible with LCC diagnosis (hypotension, oliguria, and hyponatremia) and 11 in the control group (control) matched them for gestational age without such signs. Steroids in serum were separated and pur...

The growing epidemic of obesity has led health professionals to understand the pathophysiology of obesity and its complications. Gut microbiota are of special interest, since some kinds of microbiota such as Bacteroides are less in obese persons and some microbiota induce obesity in animals by effective fat storage through microbiota-mediated intestinal Fiaf (Fasting-induced adipose factor) suppressions. Recently, bile acid-binding resins (BARs), non-absorbable drug for dyslip...

Introduction: Surgical treatment of giant GH cell adenomas (>4 cm in maximum diameter; GHomas) has been considered difficult. However, clinical and histological characteristics of these adenomas are still enigmatic. We retrospectively analyzed data of 17 giant GHomas experienced at Toranomon hospital to clarify their characteristics.Methods: These 17 patients, accounting for 3.1% of 549 acromegalic patients undergoing surgery between 2006 and 2011, w...